Basic Echocardiography (Echo)

An Echocardiogram often referred to in the medical community as a cardiac ultrasound or simply an Echo is a sonogram of the heart. It uses standard ultrasound techniques to image two-dimensional slices of the heart. The latest ultrasound system can produce 3-D real-time image. High-frequency sound waves inaudible to the human ear are sent from the probe and directed towards the heart, part of which bounces back (echoes) to the probe and is interpreted by the ultrasound machine into images, blood flow within the beating heart. The images are then displayed on the monitor and recorded on disk for future review. This test is performed either by cardiac sonographers, cardiac physiologists or doctors trained in cardiology.


Echocardiography is one of the most widely used tests for diagnosis of various heart diseases. In addition, to create two or three-dimensional picture of the heart and vessels, it can also produce the accurate assessment of the velocity of blood and cardiac tissue at any arbitrary point using pulse or continuous wave Doppler ultrasound. So this test is helpful for assessing the size of the heart chambers and walls, heart muscle function, heart valve function, blood clots or masses in the heart, fluid around the heart, presence of holes or defects between the heart chamber or vessels, anatomical relationship of various heart chambers and loops, abnormalities of blood flow within the heart etc. Doppler echo is helpful for assessment of cardiac valve areas and function, any abnormal communication between left and right heart, any leaking of blood through valves (regurgitation) and calculation of cardiac output, ejection fraction, E/A ratio etc.

Recent uses:

1. Assessment of patient for selection of various interventions like device closure of septal defects, ductus arteriosus, closure of left atrial appendage, balloon valvoplasty, angioplasty etc.
2. Guidance of interventional procedure like device closure, left atrial appendage closure, transseptal puncture, balloon atrial septostomy, stenting of duct and vessels etc.
3. Per-operative assessment of operative procedure like ASD, VSD closure, Tetralogy of Fallot repair, pulmonary artery banding, Fontan operation etc.

Types of Echocardiography:

1. Transthoracic Echocardiogram (TTE) – This is a test which takes a picture of the heart with the use of a transducer placed on the chest wall of the patient. This test is highly specific for diagnosing congenital heart disease, size of heart chambers, walls, cardiac functions, clots or masses in the heart and others.
2. Transoesophageal Echocardiography (TEE) – As opposed to the standard echocardiogram, in TEE the transducer is placed in the esophagus directly behind the heart. In addition to use by a cardiologist, TEE can be performed by a cardiac anesthesiologist to evaluate, diagnose and track patient in the pre-operative period.
3. Intracardiac Echocardiography (ICE) – ICE is an imaging technique that is becoming increasingly available as an alternative to TEE to guide the percutaneous interventional procedure. The physics of ICE are same that is used for all applications of ultrasound. The images can be displayed in M-mode, B-mode with Doppler effects and as three-dimensional reconstruction. In an electrophysiological interventional procedure, conventional ICE was used to guide the anatomic placement of the ablation catheter and to assess catheter-tissue contact. Immediate identification of complications and reduction in fluoroscopy time are other remarkable benefits of direct endocardial visualization doing radiofrequency catheter ablation. With 9 MHz ICE, detail identification of normal and abnormal structures and cardiac anatomy can be visualized with improved imaging depth. However, all ICE devices are not steerable and must be guided by a wire. Early experience with ICE suggested that this technique could evolve as a clinically useful method with diagnostic, monitoring and guidance applications possibly leading to the conversion of catheterization laboratory into integrated imaging, monitoring, and therapeutic stations. Currently, ICE is used in many centers for guiding PFO closure, ASD device closure, and trans-septal puncture procedure. It is an important tool for guiding trans-septal puncture during electrophysiological mapping and ablation procedure. It is also available or currently under development to guide other non-coronary interventions like the percutaneous placement of cardiac valves, closures devices etc. Intracardiac echocardiography can be used in EP laboratory during ablation procedure for visualization of pulmonary veins, a location of atrial-venal junction and assurance of the ablation catheter tip location within pulmonary vein antrum.

4. Fetal Echocardiography: Here probe is placed over the mother’s abdominal wall and directed towards fetal heart. This test evaluates the baby’s heart by using sound waves. This procedure provides a valuable measure to better understand intrauterine growth and development of the heart and great vessels. The prenatal diagnosis of structural heart disease and the physiological evaluation of fetal arrhythmias are perhaps the most important insights provided by this techniques. There are several potential indications for doing fetal echocardiography. Evaluation of the heart in the setting of retarded fetal growth or fetal distress is often recommended. Whenever the extracardiac anomalies are detected during fetal examination by ultrasound, cardiac assessment is indicated. Presence of chromosomal anomaly detected by amniocentesis is another indication for fetal echocardiography.
5. Stress Echocardiography – Stress echocardiography is a test that uses ultrasound imaging to determine the heart muscle response to stress.
6. Contrast Echocardiography – A small amount of liquid is injected through an IV cannula to the inside of the heart to confirm right to left shunt through patent foramen ovalae, the presence of atrial septal defect, left superior vena cava etc.
• Basic techniques used for echocardiography: Two important factors are considered in an echocardiographic examination: (1) Imaging and (2) Doppler studies

Images are two dimensional, three dimensional or real-time four-dimensional or M-mode of two-dimensional display.
Doppler studies are continuous wave Doppler, pulsed Doppler, and color flow Doppler.

A. M-mode imaging: It allows selection of an M-line form of the two-dimensional image for subsequent M-mode display. In pediatric patients, these images are used for measurement of various chamber size, ventricular pumping
function, wall thickness etc. This is a single dimension image of the heart.
B. Two-dimensional imaging: Two-dimensional echo is capable of displaying a cross-sectional “Slice” of the beating
hearts, including the chambers, valves and the major blood vessels that exit from the heart. It can give idea about size of the heart chambers, a dimension of the cavity, wall thickness, presence of any congenital defects or hole, anatomical study of structures with concordance or discordance of chamber connection, pumping function of the  heart etc.
C. 3D-4D Echocardiography: Transthoracic and trans-oesophageal echocar- Common Investigations for Heart Disease in Children diography are currently able to provide 3D reconstruction of image as well as a real-time
(4D) volumetric Echocardiography: An Important Tool for Diagnosis, Guidance of Intervention rendering of the heart. Live 3D echo is likely beneficial in cardiac surgeons pre and post-surgical planning by giving a complete accurate perspective of anatomical relationship and detecting abnormalities before surgery begins. Same is true for interventional procedures in catheterization laboratory, thus help in reducing fluoroscopy and
procedure time.
D. Doppler ultrasound: Three basic types of ultrasound technology are currently available. Continuous wave (CW) Doppler, pulsed wave (PW) Doppler and color flow Doppler. Each technique is complementary to other techniques. CW and PW Doppler apply only to a system that allows simultaneous imaging and Doppler. They can measure the velocity on sample volume. This can be measured on a frozen image or in real time. Color flow Doppler can evaluate the flow of blood within the heart and vessels. This helps detection of abnormal communication inside a heart, stenosis at any level or regurgitant jet.

Main Views of Echocardiography

1. Parasternal

a. Long Axis view(PLA)

PLA view

b. Short axis view (PSA)

PSA view

2. Apical

a. 4 Chamber view

Apical 4 chamber view

b. 5 Chamber view

chamber view

c. 2/3 Chamber view

2/3 chamber view

3. Subcostal
a. 4 Chamber view

Subcostal 4 chamber view

b. Short axis view

Short axis view

4. Suprasternal
a. Long axis view

Suprasternal long axis view

b. Short axis view

Suprasternal short axis view

2. Diagnostic Approach: Sequential Segmental Analysis

Sequential segmental analysis

It is helpful to consider the heart as a segmented
structure represented by three regions-
> Atriums
> Ventricles
> Great arteries
• Each region, in turn is partitioned into
two components, usually right sided
and left sided.
• Possibility of connection between these
three region is limited.
• Heart can also be thought of as being
like a House.
• In the cardiac house each atrium is on
the ground floor, the ventricles on the
second floor, and the position of each
great vessel is at the first floor of the
• In addition each house needs staircase
to connect the floors
• In cardiac house atrioventricular and
ventricularterial connection are the
stair case which should be in right position.

Comparison of heart segments with house

Visceral sidedness/ situs
• Situs solitus
• Situs inversus
• Situs ambiguous

Viseral situs and cardiac position
Viseral situs and cardiac position

Cardiac Position:
• Lt sided (levocardia)
• Rt sided (Dextrocardia)
• Midline (Mesocardia)

Cardiac position


Position of probe in dextrocardia
Position of IVC and aorta in situs solitus situation
Atrial morphology

Atrial isomerism

Defects in atrial septation

Atrial Septation defects are:

– Artial Septal Defects
– Patent foramen ovale
– corrmon atrium

Defects in atrio-ventricular connection

• Tricuspid stenosis / Atresia
• Ebstein anomaly
• TR
• Mitral stenosis / Atresia
• MR
• Double orifice MV
• Parachutte MV
• Double inlet left ventricle
• Common atrioventricular valve

Mitral stenosis

Ventricular morphology

Ventricular morphology

Ventricular position
Defect in septation, VSD

Ventricular hypoplasia

• Hypoplastic Rt heart syndrome
• Hypoplastic left heart syndrome

Ventricular hypoplasia



Tricuspid atresia

1. ASD
2. Tricuspid Atresia
3. VSD


Pulmonary atresia

1. PFO
2. PDA
3. Pulmonary Valve atresia
4. Hypoplastic RV




Ventriculo-arterial connection

Relationship of great vessels

Abnormalities in vessels

• A-V fistula
• Aortic arch anomalies
• Coarctation of aorta
• Interrupted Aortic Arch
• Coronary artery Fistula

Abnormalities of chamber

• Neoplasm
• Cardiomyopathy
• Vegetation
• Cardiac embolism

Cardiac neoplasm

Abnormal venous inflow

• Interrupted IVC

Echocardiography for diagnostic purpose and selection of a patient for intervention and surgery:

The echocardiography continues to play an important role in the diagnosis and assessment of response to therapy of many cardiac conditions. One of the strengths of echocardiography is that it can be brought to the patient’s bedside easily. In fact, features of ultrasound machines such as 2D, 3D, and trans-oesophageal echo, spectral and color Doppler imaging, strain rate imaging and even intracardiac imaging can be performed on devices that are increasingly portable. Many interventional procedures in the catheterization laboratory require imaging of
the heart in a manner different from fluoroscopy so that the position of the devices can be optimized. By virtue of its ease of use, lack of radiation and portability, it has come to play a key role in selecting the patient and guiding the
procedure. Transthoracic or trans-oesophageal echocardiogram with two dimensional and three-dimensional images played an important role in selecting a patient for all interventions as well as surgery. For these, some criteria’s are followed by cardiac centers to select their patients. These are:

A. Atrial Septal Defect (ASD)

a. Only secundum type.
b. Rim all around the defect should be more
than 7 mm (20% of circumference).
c. Not associated with other defects which
can not be treated non-surgically.
d. Not associated with Eisenmenger syndrome.

B. Ventricular Septal Defect (VSD)

a. All muscular VSD’s.
b. Perimembranous VSD without any inlet or outlet extension.
c. Perimembranous VSD without any aortic
regurgitation or aortic valve prolapse.
d. The distance of aortic valve from VSD margin should be more than 3 mm.
e. Not associated with arrhythmias, Eisenmenger syndrome.

C. Patent Ductus Arteriosus (PDA)

a. Almost all PDA’s are amenable to intervention.
b. Some large tubular PDA without any pocket in aortic side are excluded.
c. Eisenmenger syndromes are also contraindication.

D. Aortic valve stenosis

a. Peak pressure gradient >80 mm Hg.
b. Not associated with aortic regurgitation.
c. Dysplastic valve is a contraindication.

E. Pulmonary valve stenosis

a. Peak pressure gradient >60 mm Hg.
b. Not associated with infundibular stenosis.
c. Valve not dysplastic.

F. Percutaneous pulmonary valve implantation (In postoperative cases with RV-PA conduit).

a. Size of RV to PA conduit more than 16mm.
b. Age more than 05 years.
c. Weight more than 30 Kg.
d. Peak pressure gradient >35 mm Hg.
e. More than moderate PR.

G. Coarctation of aorta (CoA)

a. Pressure gradient across coarct segment>20 mm Hg.
b. Descrete coarctation.
c. Associated with systemic hypertension.

H. Left atrial appendage closure (Indicated for patient with nonvalvular atrial fibrillation as more than 90% of thrombi originate in left atrial appendage) Key points to be examined by echocardiography:

a. Number of lobes.
b. Exclusion of presence of thrombus inside appendage.
c. Sizing of the mouth of the appendage (from multiple views).
d. Assessment of adjacent structure eg.
Left anterior descending artery and great cardiac vein.

I. Percutaneous Transcatheter Mitral Commissurotomy (PTMC).

Echo assessment of papillary muscle, MV leaflets, chordae tendinae and annulus should be done thoroughly.

a. Mitral valve area <1.5 cm2.
b. Symptomatic patient.
c. Mobile valve.
d. Leaflet thickness-acceptable.
e. No Subvalvar involvement.

Contraindications of PTMC:

a. Presence of LA thrombus.
b. MR grade II
c. Calcification of valve.
d. Atrial fibrillation.
e. Recent history of thromboembolism.

Echo score for PTMC:

a. Score <8 acceptable.
b. Score >8 but <12 can be done.
c. Score >12 should go for surgery.

J. Transcatheter Aortic valve implantation (TAVI):

It can be performed in good surgical candidates with an expectation of an excellent outcome. However, surgery in a patient with the comorbid condition may be associated with significant mortality and morbidity. In such patient, percutaneous aortic valve replacement may offer double benefit while avoiding many of the problems associated with sternotomy, aortotomy, and cardiopulmonary bypass.

K. Stenting of Coarctation of the aorta:

A study was conducted among 40 institutions of USA; all of them considered stenting of native or recurrent coarctation of the aorta as the first choice, regardless of the severity of narrowing. The the majority (95%) would consider stent placement as the primary treatment in patient >30 kg and balloon angioplasty the treatment of
choice in patients <30 kg. No institution considered stenting in infants so far unless surgery is contraindicated. Common Investigations for Heart Disease in Children

L. Closure of patent foramen ovale (PFO):

a. Assessment of right atrial opening.
b. Assessment of left atrial opening.
c. Assessment of middle region of
overlapping to select the type of devices.
PFO should be closed in a patient before doing any second cerebrovascular accident (CVA). PFO, along with atrial septal aneurysm (ASA), has been implicated as a risk factor for cryptogamic stroke. In such cases TEE has demonstrated worm-like echogenic structures straddling the atrial septum through PFO.

M. Mitra clip for mitral regurgitation:

The E-valve mitral valve repair procedure is a novel approach for leaflet repair for mitral regurgitation. The procedure is performed via trans-septal catheterization under fluoroscopy and TEE guide. E valve mitral clip grasps the mitral leaflet and creates a double orifice, with the resultant better approximation of the mitral leaflets and diminution of the degree of MR10-14. Some of the diseases cannot be treated by intervention and they are the candidates for surgical correction.

Special diagnostic test by echocardiography:
Transthoracic and trans-oesophageal echocardiography have been used for confirmatory diagnosis of some doubtful

a. Contrast echocardiography is used to see the presence of thrombus in the left atrial appendage or left atrium. It is also used to confirm the presence of atrial septal defect, Persistent left superior vena cava in doubtful cases.

b. Transcarotid Doppler (TCD): This test is used to confirm the right to left shunt through a patent foramen ovale. CW Doppler is placed over the carotid artery and saline is injected through the cubital vein. If there is right to left
shunt then bubble appears in the CW envelope over carotid artery. The appearance of more than 10 bubbles in Doppler is positive. TCD positive patient should do his/her coagulation profile and should avoid long flight.

4. Intraoperative/Intraprocedural guidance provided by echocardiography:

The device closure procedure has traditionally been guided using a combination of fluoroscopic and two dimensional (2-D) transesophageal (TEE) and transthoracic (TTE) imaging. Because of only two dimensions, 2D is limited to detect the position of a catheter or a device relative to its surrounding structure, requiring the acquisition of multiple plane images in order to reconstruct the original setting. Recently 3D TEE is used to navigate ASD closure in an infant as well as in VSD closure. In adults, image quality by TTE is often not sufficient to guide the closing procedure adequately, like appropriate deployment and position of the device with regard to the surrounding structure. So 3D TEE is very efficient and safe technique to guide interventional procedures especially device closure of PFO, ASD, VSD etc. Nowadays, intracardiac echocardiography (ICE) can be used as the primary means for both selections of devices and guidance of transcatheter closure of secundum ASDs. With ICE planes are
identified with excellent resolution, providing proper measurements of fossa ovalis, from which to derive geometric assumption of the selection of an appropriately sized device. The ASO (Amplatzer Septal Occluder) waist diameter
is chosen in some center on the basis of the r-value( r= c² + p²).The r=radias of fossa ovalis, c is the foci half distance of fossa ovalis and p is its semilatus rectum during ASD closure. It has been shown in some study that non-conclusive TEE results found in some children with ASD can be benefited by MR imaging for determination of defect size, rim distances to adjacent structures and venous connections. Other than device closures, most frequent
interventional procedures are balloon valvotomy or angioplasty, stenting of arterial or venous stenosis, closure of intracardiac or extra cardiac communications, balloon atrial septostomy or blade atrial septectomy etc. Some structural intervention is also done like left atrial appendage closure, post myocardial infarction VSD closure, Alcohol septal oblation in HCM etc. While most of these procedures are carried out with the assistance of radiological screening, in some circumstances transoesophegeal echocardiography greatly improves the success and safety. TEE is an important part of imaging for the closure of fossa ovalis ASD, occlusion of baffle fenestration following total Common Investigations for Heart Disease in Children cavopulmonary connection, closure of congenital muscular VSD, blade atrial septectomy, PTMC, and non-urgical reduction of the ventricular septum in hypertrophic cardiomyopathy. For transseptal puncture, echocardiography is helpful to select the location of puncture site avoidiry other adjacent structure like aorta.

Some special interventional procedures:

A. Atrial septal defect (Device closure):

During device closure echocardiography helps to check followings:
1. Passage of catheter and wire through a largest hole in case of multiple ASD or fenestration.
2. Balloon sizing of the defect to look for residual shunt or presence of any other defect in the atrial septum and to determine the stretched diameter of the defect.
3. Opening of left and right atrial disc and to see whether there is any obstruction of flow to pulmonary veins or superior vena cava.
4. Any regurgitation in mitral or tricuspid valve.
5. Appearance of pericardial effusion from trauma.
6. After release of device, color flow Doppler is used to look for residual shunt.

B. Ventricular septal defect (Device closure):

Suitable conditions for device closure of VSD are
a. Muscular VSD.
b. Some of the perimembranous VSD.
c. Residual defect in the patch margin following cardiac surgery.
d. Ischemic defects following myocardial infarction.

A Combination of fluoroscopy and TEE is required for this procedures. During procedure TEE help in detecting followings:
a. Morphology and diameter of the defect.
b. Relation of semilunar and atrioventricular valve and tensor apparatus.
c. Provide information about the position of the wire, sheath and occluder during and after deployment.
d. Selection of the size and type of the occluder.
e. Left ventricular disc is deployed under echo guide followed by pull back of sheath and release of right ventricular disc.

C. Left Atrial appendage closure (LAA closure):

Transoesophegeal echocardiography is must to measure the size of the orifice, number of lobe, presence of
thrombus etc. During procedure it helps in selecting size of device, type of the device, trans septal puncture and proper placement of the fixing and sealing part of the device (ACP type) and fitting of other devices.

D. Percutaneous transcatheter mitral commissurotomy (PTMC):

TEE is essential in small children for safe perforation of the atrial septum and for precise positioning of the balloon dilatation catheter across the mitral valve, avoiding damage to the tension apparatus.

E. Alcohol septal ablation in hypertrophic cardiomyopathy:

Procedure is monitored with TEE for precise imaging of the injection of alcohol by delineating the area with a myocardial contrast agent, injected directly through coronary catheter.

Echocardiography in monitoring, guiding and evaluating surgical repair of congenital malformation:

Trans-oesophageal echocardiography is a useful tool to determine the strategies for treatment in the preoperative period and to improve the quality of surgical procedures in children with congenital heart disease. Accuracy of surgical procedure can be assessed preoperatively during VSD closure, RVOT resection, TAPVD repair and many other occasions. Residual problems or sequee are identified in immediate post-operative period and some patient may go for re-intervention or return to bypass for modification of the surgical procedure.

Post-operative and post interventional follow up of the patient by echocardiography

Every interventional and surgical procedures Common Investigations for Heart Disease in Children needs follow up evaluation to look for outcome, complications, residual problems etc. So every patient need to be evaluated routinely at regular interval from cardiology and cardiac surgery out-patient department by ECG, Chest X-ray
and most importantly by transthoracic echocardiography. If any complications or residual problem are noticed, that should be addressed properly without making delay. Some of the patient may need redo surgery. Some case of
device closure patients have late device embolization in many centers in inexperienced hand, which can be identified by echocardiography. The aim of echocardiography is to determine the anatomy of the heart, assessing the function of all components, detecting abnormal features, to look at the normal flow through valves and tracts or abnormal flow or shunts.

A dedicated and experienced echo cardiographer can provide diagnostic and follow up services to the patient up to the mark.

Indication for Echocardiography in Children:
1. Infant of Diabetic Mother, Mother with SLE, Mother with a history of wake hormones, warfarin, anticonvulsants.
2. Syndromic baby
3. Baby with congenital malformation
4. Cyanotic baby not improved with oxygenation
5. Murmur in precordium
6. Preterm and VLBW
7. Family H/O CHD.
8. Patient with unexplained shock or acidosis.
9. Recurrent RTI

Protocol for fetal Echocardiography schedule:

• High-risk mother:

I. 1st scan (Echo) 12 weeks of pregnancy.
II. 2nd scan (Echo) 18 weeks of pregnancy.
III. 3rdscan (Echo) 32 weeks of pregnancy.

• The timing of fetal Echo for others:

18 weeks of pregnancy.

*Special attention: After 18 weeks scan (Echo), if major anomaly presents then decide for abortion by 20 weeks.

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